By road: the drive is approximately 9hrs from Calais, via motorway virtually the whole way. St. Gervais is 4 miles from the A40 Motorway. (Please note that the drive and access road is steep, so snow chains are essential in winter, even for 4 wheel drive vehicles.)
Look at the following links for maps and directions:
By rail: TGV direct from Paris (5 hrs) to St. Gervais/Le Fayet station.
By air: Fly to Geneva airport, then hire a car for the 1hour 15minute drive to St. Gervais. From the UK try: Easyjet, BA, Expedia, Last Minute, TravelBag